Catch-up growth after prolonged hypothyroidism

Catch-up Growth

Catch-up growth.

Catch-up growth, defined as growth velocity above the statistical limits of normality for age or maturity during a defined period of time, is distinguished from compensatory growth since it makes up for a potential loss rather than an actual loss and is seen in the whole body as opposed to specific organs. The cellular explanation for catch-up based on the work of Winick is described and a rece...

Congenital Hypothyroidism: Effects on Linear Growth, Catch-Up Growth, GH-IGF-I Axis and Bones

Triiodothyronine (T3) is a primary determinant of normal postnatal somatic growth and skeletal development, and an important regulator of bone and mineral metabolism in hu‐ man [1, 2]. Before puberty, thyroid hormone appears to be a major prerequisite for normal maturation of bone [3]. Untreated childhood hypothyroidism results in a profound growth retardation and a delayed skeletal maturation....

Late "catch-up" growth after severe infantile malnutrition.

Prolonged observations of children severely malnourished in early life suggested that permanent stunting in body length and head size resulted (1, 2). Studies with small laboratory animals lent support to these observations (3). Besides the obvious species differences, there were other important distinctions between the two types of studies. Whereas the experimental animals after the early insu...

Nutritionally-Induced Catch-Up Growth

Malnutrition is considered a leading cause of growth attenuation in children. When food is replenished, spontaneous catch-up (CU) growth usually occurs, bringing the child back to its original growth trajectory. However, in some cases, the CU growth is not complete, leading to a permanent growth deficit. This review summarizes our current knowledge regarding the mechanism regulating nutrition a...